16 / 07 / 2022
Cancer letters
Predictive biomarkers for personalized medicine in breast cancer
Sylvie Rodrigues-Ferreira, Clara Nahmias
Breast cancer is one of the most frequent malignancies among women worldwide. Based on clinical and molecular features of breast tumors, patients are treated with chemotherapy, hormonal therapy and/or radiotherapy and more recently with immunotherapy or targeted therapy. These different therapeutic options have markedly improved patient outcomes. However, further improvement is needed to fight against resistance to treatment...
06 / 06 / 2022
Cancer letters
Dysfunction of calcium-regulated exocytosis at a single-cell level causes catecholamine hypersecretion in patients with pheochromocytoma
Sébastien Houy, Laura Streit, Inès Drissa, Marion Rame, ..., Stéphane Ory, Stéphane Gasman
Neuroendocrine tumors constitute a heterogeneous group of tumors arising from hormone-secreting cells and are generally associated with a dysfunction of secretion. Pheochromocytoma (Pheo) is a neuroendocrine tumor that develops from chromaffin cells of the adrenal medulla, and is responsible for an excess of catecholamine secretion leading to severe clinical symptoms such as hypertension, elevated stroke risk and various cardiovascular complications. Surprisingly, while the hypersecretory activity of Pheo is well known to pathologists and clinicians, it has never been carefully explored at the cellular and molecular levels...
30 / 05 / 2022
Scientific Reports
The melanopsin-mediated pupil response is reduced in idiopathic hypersomnia with long sleep time
Héloïse Rach, Ulker Kilic-Huck, Eve Reynaud,..., Fanny Fuchs, Patrice Bourgin, Pierre A Geoffroy
Idiopathic hypersomnia (IH), characterized by an excessive day-time sleepiness, a prolonged total sleep time on 24 h and/or a reduced sleep latency, affects 1 in 2000 individuals from the general population. However, IH remains underdiagnosed and inaccurately treated despite colossal social, professional and personal impacts. The pathogenesis of IH is poorly known, but recent works have suggested possible alterations of phototransduction...
20 / 05 / 2022
Cancers (Basel)
Tumor-Infiltrating Lymphocytes (TILs) in Early Breast Cancer Patients: High CD3 +, CD8 +, and Immunoscore Are Associated with a Pathological Complete Response
Bernardo Leon Rapoport, Simon Nayler, Bernhard Mlecnik, Teresa Smit,..., Jérôme Galon, Carol-Ann Benn, Ronald Anderson
Tumor-infiltrating lymphocytes are associated with a better prognosis in early triple-negative breast cancer (TNBC). These cells can be enumerated in situ by the "Immunoscore Clinical Research" (ISCR). The original Immunoscore® is a prognostic tool that categorizes the densities of CD3+ and CD8+ cells in both the invasive margin (IM) and center of the tumor (CT) in localized colon cancer, yielding a five-tiered classification (0-4). We evaluated the prognostic potential of ISCR and pathological complete response (pCR) following neoadjuvant chemotherapy (NACT).
27 / 04 / 2022
Frontiers in Immunology
Dissecting the Role of AXL in Cancer Immune Escape and Resistance to Immune Checkpoint Inhibition
Agnete S T Engelsen, Maria L Lotsberg, Raefa Abou Khouzam, Jean-Paul Thiery, James B Lorens, Salem Chouaib, Stéphane Terry
The development and implementation of Immune Checkpoint Inhibitors (ICI) in clinical oncology have significantly improved the survival of a subset of cancer patients with metastatic disease previously considered uniformly lethal. However, the low response rates and the low number of patients with durable clinical responses remain major concerns and underscore the limited understanding of mechanisms regulating anti-tumor immunity and tumor immune resistance...
08 / 04 / 2022
JCI Insight
TET2 regulates immune tolerance in chronically activated mast cells
Riccardo Rigo, Rabie Chelbi, Julie Agopian, ..., Olivier A Bernard, Patrice Dubreuil, Erinn Soucie
Mutation of the TET2 DNA-hydroxymethylase has been associated with a number of immune pathologies. The disparity in phenotype and clinical presentation among these pathologies leads to questions regarding the role of TET2 mutation in promoting disease evolution in different immune cell types. Here we show that, in primary mast cells, Tet2 expression is induced in response to chronic and acute activation signals...