05 / 05 / 2024
Differential functional organization of amygdala-medial prefrontal cortex networks in macaque and human
Camille Giacometti, Delphine Autran-Clavagnier, Audrey Dureux, Laura Viñales, Franck Lamberton, Emmanuel Procyk, Charles R E Wilson, Céline Amiez, Fadila Hadj-Bouziane
Over the course of evolution, the amygdala (AMG) and medial frontal cortex (mPFC) network, involved in behavioral adaptation, underwent structural changes in the old-world monkey and human lineages. Yet, whether and how the functional organization of this network differs remains poorly understood. Using resting-state functional magnetic resonance imagery, we show that the functional connectivity (FC) between AMG nuclei and mPFC regions differs between humans and awake macaques...
22 / 04 / 2024
Nature communications
PD-L1- and IL-4-expressing basophils promote pathogenic accumulation of T follicular helper cells in lupus
John Tchen, Quentin Simon, Léa Chapart, Morgane K Thaminy, Shamila Vibhushan, Loredana Saveanu, Yasmine Lamri, Fanny Saidoune, Emeline Pacreau, Christophe Pellefigues, Julie Bex-Coudrat, Hajime Karasuyama, Kensuke Miyake, Juan Hidalgo, Padraic G Fallon, Thomas Papo, Ulrich Blank, Marc Benhamou, Guillaume Hanouna, Karim Sacre, Eric Daugas, Nicolas Charles
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by anti-nuclear autoantibodies whose production is promoted by autoreactive T follicular helper (TFH) cells. During SLE pathogenesis, basophils accumulate in secondary lymphoid organs (SLO), amplify autoantibody production and disease progression through mechanisms that remain to be defined. Here, we provide evidence for a direct functional relationship between TFH cells and basophils during lupus pathogenesis, both in humans and mice...
09 / 02 / 2024
Nature communications
Endogenous cannabinoids in the piriform cortex tune olfactory perception
Geoffrey Terral, Evan Harrell, Gabriel Lepousez, Yohan Wards, Dinghuang Huang, Tiphaine Dolique, Giulio Casali, Antoine Nissant, Pierre-Marie Lledo, Guillaume Ferreira, Giovanni Marsicano, Lisa Roux
Sensory perception depends on interactions between external inputs transduced by peripheral sensory organs and internal network dynamics generated by central neuronal circuits. In the sensory cortex, desynchronized network states associate with high signal-to-noise ratio stimulus-evoked responses and heightened perception...
03 / 02 / 2024
Molecular therapy
DLK1/DIO3 locus upregulation by a β-catenin-dependent enhancer drives cell proliferation and liver tumorigenesis
Julie Sanceau, Lucie Poupel, Camille Joubel, Isabelle Lagoutte,..., Christophe F Grosset, Jessica Zucman-Rossi, Sabine Colnot, Angélique Gougelet
The CTNNB1 gene, encoding β-catenin, is frequently mutated in hepatocellular carcinoma (HCC, ∼30%) and in hepatoblastoma (HB, >80%), in which DLK1/DIO3 locus induction is correlated with CTNNB1 mutations. Here, we aim to decipher how sustained β-catenin activation regulates DLK1/DIO3 locus expression and the role this locus plays in HB and HCC development in mouse models deleted for Apc (ApcΔhep) or Ctnnb1-exon 3 (β-cateninΔExon3) and in human CTNNB1-mutated hepatic cancer cells...
29 / 01 / 2024
Frontiers in Physiologie
Understanding bovine embryo elongation: a transcriptomic study of trophoblastic vesicles
Séverine A Degrelle, Fulin Liu, Denis Laloe, Christophe Richard, Daniel Le Bourhis, Marie-Noëlle Rossignol, Isabelle Hue
During the process of elongation, the embryo increases in size within the uterus, while the extra-embryonic tissues (EETs) develop and differentiate in preparation for implantation. As it grows, the ovoid embryo transforms into a tubular form first and then a filamentous form. This process is directed by numerous genes and pathways, the expression of which may be altered in the case of developmental irregularities such as when the conceptus is shorter than expected or when the embryo develops after splitting...
06 / 12 / 2023
Bursting with Potential: How Sensorimotor Beta Bursts Develop from Infancy to Adulthood
Holly Rayson Maciej J Szul, Perla El-Khoueiry, Ranjan Debnath, Marine Gautier-Martins, Pier F Ferrari, Nathan Fox, James J Bonaiuto
Beta activity is thought to play a critical role in sensorimotor processes. However, little is known about how activity in this frequency band develops. Here, we investigated the developmental trajectory of sensorimotor beta activity from infancy to adulthood. We recorded EEG from 9-month-old, 12-month-old, and adult humans (male and female) while they observed and executed grasping movements. We analyzed "beta burst" activity using a novel method that combines time-frequency decomposition and principal component analysis...
